The development of MNX induced and spontaneous OA was

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steriods Furthermore, the effects of clenbuterol induced quadriceps hypertrophy, prior to the induction of OA, on disease severity were considered in the rat MNX model. Thus far, the cDNA sequences encoding each member of the myosin heavy chain (MHC) gene family have yet to be determined in the guinea pig. Therefore, a further aim of this work was to generate novel cDNA sequence pertaining to the skeletal muscle associated isoforms of MHC in the guinea pig, and to develop specific oligonucleotide primers to determine the abundance of each specific mRNA.The development of MNX induced and spontaneous OA was associated with changes in MHC I expression indicative of an increase in slow, type I muscle fibres. steriods

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